生体再現学研究室 (岐阜薬科大学サテライト研究室)

Laboratory of Bioengineering, Gifu Pharmaceutical University

論文業績

最近の主要論文（ヒトiPS細胞由来のオルガノイド研究）

  1. Generation of bioengineered liver grafts densely recellularized using human liver organoids
    Sonoda K., Yagi H., Nagata S., Tsuchida T., Nishi K., Morisaku T., Ohtomo M., Adachi S., Okamoto S., Kamishibahara Y., Kuse Y., Taniguchi H., Kitagawa Y.
    Cell Transplantation. 2026

  2. Oxygenated Perfusion Enhances Hepatocyte Function in Human iPSC-liver Tissue.
    Yamabe S.‡, Kuse Y.‡, Okumura T., Kasai T., Nishi K., Tsuchida T., Ohtomo M., Yagi H., Sakai H., Yamaguchi K., Furukawa Y., Tanimizu T., Taniguchi H. Transplantation. 2026 (‡Equal contribution)

  3. Placenta-derived factors contribute to human iPSC-liver organoid growth.
    Kuse Y., Matsumoto S., Tsuzuki S., Carolina E., Okumura T., Kasai T., Yamabe S., Yamaguchi K., Furukawa Y., Tadokoro T., Ueno Y., Oba T., Tanimizu N., Taniguchi H. Nature communications. 2025

  4. Establishment of vascularized human retinal organoids from induced pluripotent stem cells.
    Inagaki S.‡, Nakamura S.‡, Kuse Y.‡, Aoshima K., Funato M., Shimazawa M., Hara H. Stem Cells. 2025 (‡Equal contribution)

  5. Establishment of human Leber’s hereditary optic neuropathy model using iPSC-derived retinal organoids.
    Aoshima K., Takagi Y., Funato M., Kuse Y., Nakamura S., Shimazawa M. Frontiers in Cellular Neuroscience, 2025

  6. Generation of human iPSC-derived 3D bile duct within liver organoid by incorporating human iPSC-derived blood vessel.
    Carolina E., Kuse Y., Okumura A., Aoshima K., Tadokoro T., Matsumoto S., Kanai E., Okumura T., Kasai T., Yamabe S., Nishikawa Y., Yamaguchi K., Furukawa Y., Tanimizu N., Taniguchi H. Nature Communications. 2024

  7. Human iPSC–liver organoid transplantation reduces fibrosis through immunomodulation.
    Tadokoro T., Murata S., Kato M., Ueno Y., Tsuchida T., Okumura A., Kuse Y., Konno T., Uchida Y., Yamakawa Y., Zushi M., Yajima M., Kobayashi T., Hasegawa S., Kawakatsu-Hatada Y., Hayashi Y., Osakabe S., Maeda T., Kimura K., Mori A., Tanaka M., Kamishibahara Y., Matsuo M., Nie Y.Z., Okamoto S., Oba T., Tanimizu N., Taniguchi H. Science Translational Medicine. 2024

その他論文

  1. Age-dependent induction of ER stress in retinal pigment epithelium impairs phagocytosis via ADAM17-dependent MERTK shedding.
    Yasuda H., Nakamura S., Shirakawa A., Kuse Y., Mori K., Shimazawa M. Journal of Biological Chemistry. 2026
  2. Protective effects of a highly water-soluble rutin on cognitive dysfunction in mice. Honoka Fujimori, Takuya Ohba, Yoshiki Kuse, Shinsuke Nakamura, Hiroaki Kida, Takeshi Okada, Naoto Yamaguchi, Hideaki Hara, Masamitsu Shimazawa. Journal of Pharmacological Sciences, 2026
  3. Inhibition of Pathological Mitochondrial Fission in Retinal Pigment Epithelium Mitigates Choroidal Neovascularization. Hiroto Yasuda, Shinsuke Nakamura, Aimi Shirakawa, Yoshiki Kuse, Masamitsu Shimazawa. Investigative Ophthalmology & Visual Science, 2026
  4. Detrimental Effect of Early Clazosentan Administration on Neurogenic Pulmonary Edema Following Subarachnoid Hemorrhage and Safety of Its Delayed Administration: Laboratory Investigation. Nozomi Sasaki, Yusuke Egashira, Shinomi Sasaibe, Masaki Kumagai, Yoshiki Kuse, Shinsuke Nakamura, Hirofumi Matsubara, Yukiko Enomoto, Toru Iwama, Tsuyoshi Izumo, Hideaki Hara, Masamitsu Shimazawa. World Neurosurgery, 2026
  5. Pulmonary edema following subarachnoid hemorrhage is associated with impairment of pulmonary vascular endothelial glycocalyx. Nozomi Sasaki, Yusuke Egashira, Hideshi Okada, Chihiro Takada, Shinomi Sasaibe, Masaki Kumagai, Yoshiki Kuse, Shinsuke Nakamura, Hirofumi Matsubara, Yukiko Enomoto, Toru Iwama, Tsuyoshi Izumo, Hideaki Hara, Masamitsu Shimazawa. Biochemistry and Biophysics Reports, 2025
  6. The Involvement of HYBID in the Regulation of Intraocular Pressure and Extracellular Matrix Accumulation in the Trabecular Meshwork. Yuya Takagi, Kota Aoshima, Yoshiki Kuse, Shinsuke Nakamura, Yasunori Okada, Masamitsu Shimazawa. Biological and Pharmaceutical Bulletin, 2025
  7. Synergistic antitumor and radiosensitizing effects of α-sulfoquinovosyl-acylpropanediol (SQAP) via PI3K/Akt inhibition and DNA repair impairment in glioblastoma. Takayuki Nishiwaki, Urara Kudo, Shinsuke Nakamura, Yoshiki Kuse, Yoshiaki Harakawa, Fukka You, Kenji Shoda, Tetsuya Yamada, Hiroaki Takei, Yusuke Egashira, Hideaki Hara, Noriyuki Nakayama, Tsuyoshi Izumo, Masamitsu Shimazawa. Journal of neuro-oncology, 2025
  8. ZLN005, a PGC-1α transcriptional activator, exacerbates cardiac function following myocardial infarction in a permanent occlusion model. Taiga Okumura, Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa. Biochemical and biophysical research communications. 2025
  9. Mitochonic acid 5, an ATP production accelerator, protects against neurological damage in ischemic stroke. Shinomi Sasaibe, Yukie Yoshioka, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa, Brain Research. 2025 
  10. The anti-angiogenic effects of arctigenin on choroidal neovascularization pathogenesis. Aimi Shirakawa, Hiroto Yasuda, Shinsuke Nakamura, Yuichi Takajo, Satoshi Inamasu, Satoshi Yomoda, Shimpei Watanabe, Yoshiki Kuse, Masamitsu Shimazawa. Journal of pharmacological sciences, 2025
  11. Microthrombosis at the Ultra-early Stages after Experimental Subarachnoid Hemorrhage Results in Early Brain Injury. Masaki Kumagai, Yusuke Egashira, Nozomi Sasaki, Shinsuke Nakamura, Yoshiki Kuse, Hirohumi Matsubara, Yukiko Enomoto, Tsuyoshi Izumo, Hideaki Hara, Masamitsu Shimazawa. Current Neurovascular Research. 2024
  12. Intranasal administration of liposomes: Potential brain delivery with prospective ophthalmic reach. Shohei Tsuji, Riku Hatano, Shinsuke Nakamura, Urara Kudo, Kota Aoshima, Honoka Fujimori, Yuya Takagi, Mayuna Obayashi, Takaaki Ito, Eriko Yamazoe, Yoshiki Kuse, Wataru Otsu, Masamitsu Shimazawa, Kohei Tahara. Journal of Drug Delivery Science and Technology. 2024
  13. NAMPT Activator P7C3-A20 Protects against Tunicamycin-Induced Cell Injury in C2C12 Murine Myoblast Cells. Naoki Chinen, Wataru Otsu, Yoshiki Kuse, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa. BPB Reports. 2024
  14. Progranulin-deficient macrophages cause cardiotoxicity under hypoxic conditions. Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa. Biochemical and biophysical research communications.2024
  15. Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell-derived neural crest cells. Mukae K, Takenobu H, Endo Y, Haruta M, Shi T, Satoh S, Ohira M, Funato M, Toguchida J, Osafune K, Nakahata T, Kanda H, Kamijo T. Cancer Sci. 2023
  16. Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction. Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara. FASEB BioAdvances. 2023
  17. VGF nerve growth factor inducible has the potential to protect pancreatic β-cells. Hikari Hirakida, Taiga Okumura, Ryosuke Fujita, Yoshiki Kuse, Takahiro Mizoguchi, Satoshi Inagaki, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara. Journal of Endocrinology. 2023
  18. Ropinirole Prevents Light-Induced Retinal Photoreceptor Damage in Mice. Miruto Tanaka, Yuki Inoue, Yuta Yoshino, Yoshiki Kuse, Norifumi Tanida, Koichi Takahashi, Yohei Miyamoto, Hideaki Hara. BPB Reports. 2021
  19. Distribution of Carotenoids and Protective Effects of Zeaxanthin on Retina of Ayu Sweetfish (Plecoglossus altivelis). Shinsuke Nakamura, Takashi Maoka, Yoshiki Kuse, Aomi Muramatsu, Yuta Yoshino, Masamitsu Shimazawa, Hideaki Hara. Journal of oleo science. 2020
  20. Effects of progranulin on the pathological conditions in experimental myocardial infarction model. Takahiro Sasaki, Masamitsu Shimazawa, Hiromitsu Kanamori, Yoshihisa Yamada, Anri Nishinaka, Yoshiki Kuse, Genjiro Suzuki, Tomomi Masuda, Shinsuke Nakamura, Masato Hosokawa, Shinya Minatoguchi, Hideaki Hara. Scientific reports. 2020
  21. The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cell. Emi Ooe, Tomohiro Yako, Yoshiki Kuse, Tetsuya Sogon, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara. Journal of Nutritional Food. 2020
  22. The Protective Effects of Levetiracetam on a Human iPSCs-Derived Spinal Muscular Atrophy Model. Ando S, Funato M, Ohuchi K, Inagaki S, Sato A, Seki J, Kawase C, Saito T, Nishio H, Nakamura S, Shimazawa M, Kaneko H, Hara H. Neurochem Res. 2019
  23. Impairment of oligodendrocyte lineages in spinal muscular atrophy model systems. Ohuchi K, Funato M, Ando S, Inagaki S, Sato A, Kawase C, Seki J, Nakamura S, Shimazawa M, Kaneko H, Hara H. Neuroreport. 2019
  24. Notch Signaling Mediates Astrocyte Abnormality in Spinal Muscular Atrophy Model Systems. Ohuchi K, Funato M, Yoshino Y, Ando S, Inagaki S, Sato A, Kawase C, Seki J, Saito T, Nishio H, Nakamura S, Shimazawa M, Kaneko H, Hara H. Sci Rep. 2019
  25. The Protective Effect of Blue Light Cutting Particles Mixed Optical Material against Blue LED Light-Induced Photoreceptor and Cornea Cell Death. Tomohiro Yako, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa, Takashi Motomura, Hideaki Hara. Journal of Science and Technology in Lighting. 2019
  26. Carteolol hydrochloride reduces visible light-induced retinal damage in vivo and BSO/glutamate-induced oxidative stress in vitro. Matsuo M, Kuse Y, Takahashi K, Kuwahara K, Tanito M, Kaidzu S, Shimazawa M, Hara H, Ohira A. Journal of pharmacological sciences, 2019
  27. Potential effects of progranulin and granulins against retinal photoreceptor cell degeneration. Miruto Tanaka, Yoshiki Kuse, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa. Molecular vision. 2019
  28. VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush. Takeuchi H, Inagaki S, Morozumi W, Nakano Y, Inoue Y, Kuse Y, Mizoguchi T, Nakamura S, Funato M, Kaneko H, Hara H, Shimazawa M. Scientific reports. 2018
  29. Edaravone is a candidate agent for spinal muscular atrophy: In vitro analysis using a human induced pluripotent stem cells-derived disease model. Ando S, Funato M, Ohuchi K, Kameyama T, Inagaki S, Seki J, Kawase C, Tsuruma K, Shimazawa M, Kaneko H, Hara H. Eur J Pharmacol. 2017
  30. A Docosahexaenoic Acid-Derived Pro-resolving Agent, Maresin 1, Protects Motor Neuron Cells Death. Ohuchi K, Ono Y, Joho M, Tsuruma K, Ogami S, Yamane S, Funato M, Kaneko H, Nakamura S, Hara H, Shimazawa M. Neurochem Res. 2018
  31. Impaired Cerebellar Development in Mice Overexpressing VGF. Mizoguchi T, Shimazawa M, Ohuchi K, Kuse Y, Nakamura S, Hara H. Neurochemical research. 2018
  32. Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival. Yuichi Saito, Yoshiki Kuse, Yuki Inoue, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa. Redox Biology. 2018
    Intravitreal aflibercept protects photoreceptors of mice against excessive light exposure. Kuse Y, Takahashi K, Inoue Y, Izawa H, Nakamura S, Shimazawa M, Hara H. Journal of pharmacological sciences. 2018
  33. Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice. Nakamura M, Yako T, Kuse Y, Inoue Y, Nishinaka A, Nakamura S, Shimazawa M, Hara H. Experimental eye research. 2018
  34. Microglia increases the proliferation of retinal precursor cells during postnatal development. Yoshiki Kuse, Kazuki Ohuchi, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa. Molecular vision. 2018
  35. Bilberry extract and anthocyanins suppress unfolded protein response induced by exposure to blue LED light of cells in photoreceptor cell line. Ooe E, Kuse Y, Yako T, Sogon T, Nakamura S, Hara H, Shimazawa M. Molecular vision. 2018
  36. Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Kondo Y, Toyoda T, Ito R, Funato M, Hosokawa Y, Matsui S, Sudo T, Nakamura M, Okada C, Zhuang X, Watanabe A, Ohta A, Inagaki N, Osafune K. Diabetologia. 2017
  37. Insulin-producing cells derived from ‘induced pluripotent stem cells’ of patients with fulminant type 1 diabetes: Vulnerability to cytokine insults and increased expression of apoptosis-related genes. Hosokawa Y, Toyoda T, Fukui K, Baden MY, Funato M, Kondo Y, Sudo T, Iwahashi H, Kishida M, Okada C, Watanabe A, Asaka I, Osafune K, Imagawa A, Shimomura I. J Diabetes Investig. 2017
  38. Progranulin increases phagocytosis by retinal pigment epithelial cells in culture. Hiromi Murase, Kazuhiro Tsuruma, Yoshiki Kuse, Masamitsu Shimazawa, Hideaki Hara. Journal of Neuroscience Research. 2017
  39. Platelet-derived growth factor-bb lessens light-induced rod photoreceptor damage in mice. Kei Takahashi, Masamitsu Shimazawa, Hiroshi Izawa, Yuki Inoue, Yoshiki Kuse, Hideaki Hara. Investigative Ophthalmology and Visual Science. 2017
  40. The Involvement of the Oxidative Stress in Murine Blue LED Light-Induced Retinal Damage Model. Maho Nakamura, Yoshiki Kuse, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara. Biological & pharmaceutical bulletin. 2017
  41. Molecular and cellular pharmacology Protective effects of fluoroquinolones on UV-induced damage of cultured ocular cell lines. Takashi Nishida, Yoshiki Kuse, Kiyofumi Mochizuki, Masamitsu Shimazawa, Tetsuya Yamamoto, Hideaki Hara. European Journal of Pharmacology. 2017
  42. Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration. Yuki Inoue, Masamitsu Shimazawa, Ryota Nagano, Yoshiki Kuse, Kei Takahashi, Kazuhiro Tsuruma, Masahiro Hayashi, Takashi Ishibashi, Takashi Maoka, Hideaki Hara. Journal of pharmacological sciences. 2017
  43. RS9, a novel Nrf2 activator, attenuates light-induced death of cells of photoreceptor cells and Müller glia cells. Inoue Y, Shimazawa M, Noda Y, Nagano R, Otsuka T, Kuse Y, Nakano Y, Tsuruma K, Nakagami Y, Hara H. Journal of neurochemistry. 2017
  44. Progranulin deficiency causes the retinal ganglion cell loss during development. Yoshiki Kuse, Kazuhiro Tsuruma, Takahiro Mizoguchi, Masamitsu Shimazawa, Hideaki Hara. Scientific reports. 2017
  45. CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure. Yoshiki Kuse, Kazuhiro Tsuruma, Yusuke Kanno, Masamitsu Shimazawa, Hideaki Hara. Frontiers in Pharmacology. 2017
  46. The involvement of ATF4 and S-opsin in retinal photoreceptor cell damage induced by blue LED light. Emi Ooe, Kazuhiro Tsuruma, Yoshiki Kuse, Saori Kobayashi, Masamitsu Shimazawa, Hideaki Hara. Molecular vision. 2017
  47. Nrf2 protects photoreceptor cells from photo-oxidative stress induced by blue light. Wan-Ju Chen, Caiying Wu, Zhenhua Xu, Yoshiki Kuse, Hideaki Hara, Elia J. Duh. Experimental eye research. 2017
  48. Characterization of an L-Carnitine Transport System in Murine Photoreceptor Cell Line. Yuta Ohno, Yusuke Otsuka, Masakatsu Nohara, Tomomi Furihata, Yoshiki Kuse, Yoshinori Itoh, Hideaki Hara, Naohiko Anzai. Biological & pharmaceutical bulletin. 2017
  49. Established Stem Cell Model of Spinal Muscular Atrophy Is Applicable in the Evaluation of the Efficacy of Thyrotropin-Releasing Hormone Analog. Ohuchi K, Funato M, Kato Z, Seki J, Kawase C, Tamai Y, Ono Y, Nagahara Y, Noda Y, Kameyama T, Ando S, Tsuruma K, Shimazawa M, Hara H, Kaneko H. Stem Cells Transl Med. 2016
  50. Colored lenses suppress blue light-emitting diode light-induced damage in photoreceptor-derived cells. Kaho Hiromoto, Yoshiki Kuse, Kazuhiro Tsuruma, Nobuyuki Tadokoro, Nobuyuki Kaneko, Masamitsu Shimazawa, Hideaki Hara. Journal of Biomedical Optics. 2016
  51. Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina. Yoshiki Kuse, Kazuhiro Tsuruma, Sou Sugitani, Hiroshi Izawa, Yuta Ohno, Masamitsu Shimazawa, Hideaki Hara. Scientific reports. 2016
  52. Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells. Toyoda T, Mae S, Tanaka H, Kondo Y, Funato M, Hosokawa Y, Sudo T, Kawaguchi Y, Osafune K. Stem Cell Res. 2015
  53. Photobiomodulation with 670 nm light increased phagocytosis in human retinal pigment epithelial cells. Shinichiro Fuma, Hiromi Murase, Yoshiki Kuse, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara. Molecular Vision. 2015
  54. Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells. Gotoh S, Ito I, Nagasaki T, Yamamoto Y, Konishi S, Korogi Y, Matsumoto H, Muro S, Hirai T, Funato M, Mae S, Toyoda T, Sato-Otsubo A, Ogawa S, Osafune K, Mishima M. Stem Cell Reports. 2014
  55. Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light. Yoshiki Kuse, Kenjiro Ogawa, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara. Scientific reports. 2014
  56. Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro. Kenjirou Ogawa, Yoshiki Kuse, Kazuhiro Tsuruma, Saori Kobayashi, Masamitsu Shimazawa, Hideaki Hara. BMC complementary and alternative medicine. 2014
  57. The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage. Sou Sugitani, Kazuhiro Tsuruma, Yuta Ohno, Yoshiki Kuse, Mika Yamauchi, Yusuke Egashira, Shinichi Yoshimura, Masamitsu Shimazawa, Toru Iwama, Hideaki Hara. Experimental eye research. 2013